With the inclusion of an alternate version of Miller, King and Fornés are drilling into the idea that 1985 was an exceptionally pivotal period in real superhero comics history as well, when Watchmen, The Dark Knight Returns, and Crisis on Infinite Earths all hit stands in a span of a couple years. 2, 1985, and presumably changes American culture forever. In Watchmen, the squid hits New York on Nov. Otto Binder believed that humans were descended from alien visitors, writing several books on the subject.Īlan Moore and Dave Gibbons established a warped comics industry in their version of American history, but they didn’t make such direct one-to-one parallels with pirate comics and actual superhero creators. Steve Ditko eventually became a recluse in his New York City apartment. Like Mister Miracle, Rorschach is examining a comics creator who never got his due, but Rorschach has a particular focus on comics creators who are considered to have gone off the deep end later in life. His Mister Miracle, created with Mitch Gerads, cast a young Stan Lee as the character Funky Flashman, and repeatedly referenced the life of Mister Miracle creator Jack Kirby. Rorschach isn’t the first comic where Tom King has brought real comic book history into the fiction. A few months later, the squid hit Manhattan, and he never wrote another comic again.īut a little bit before their deaths, Wil Myerson and his lady friend showed up on Miller’s doorstep to conduct another seance, and together they convinced themselves that Doctor Manhattan needed them to kill a presidential candidate to save the world from the squids. In Rorschach, Miller is famous for writing a comic called The Dark Fife, an attempt to take a popular, cheerful pirate character called Seaman and turn him into a meditation on fear. Yep, Frank Miller, of Daredevil, Sin City, Batman: Year One, and most importantly The Dark Knight Returns, exists in the Watchmen setting now. Until Rorschach #7, when things get literally real. Image: Tom King, Jorge Fornés/DC Comics and Photo by Mireya Acierto/FilmMagic It’s a strange bit of ephemera, and the inclusion of a real and living comics creator makes it stand out, but Rorschach gave the reader nothing in the rest of its story to connect it to. Otto Binder ( Captain Marvel, co-creator of Supergirl), Wil Myerson (fictional stand in for Steve Ditko), Frank Miller, and a journalist friend of Miller’s called Randy. In the first issue of Rorschach, our detective lead comes across a recording of a seance attended by a mix of real comics luminaries and stand-ins created by King and Fornés. She swept him up in her quest to find the person who she believes is the unaware reincarnation of Rorschach, created by Doctor Manhattan, and save the world from the squids. Myerson was in that arena and trying to kill Turley because after decades of obscurity and personal frustrations, he was contacted by a troubled young girl who was raised by a father obsessed with conspiracy theories about a coming squid invasion. Ditko directly inspired Alan Moore to create Rorschach, as a kind of parody of his later work, bringing the theme full circle. Over the course of the series, it’s become abundantly clear that Myerson is a stand in for comics writer and artist Steve Ditko, co-creator of Spider-Man and infamous later-in-life-weirdo. Most of Rorschach has been concerned with the fate of Wil Myerson, who first appears in the comic as an elderly man who is killed as he tries to assassinate a presidential candidate by the name of Turley. The Pontius Pirate franchise, a box office smash in Rorschach, is a stand in for superhero blockbusters in general, and Spider-Man specifically. In part, that’s because the creators have so far avoided talking much about masked avengers in order to focus on Watchmen’s version of the American comics industry, which, if you remember your Watchmen facts, is dominated by stories about pirates rather than superheroes.īut in this week’s Rorschach #7, the two have reimagined one of the biggest names in comics’ Modern Age as a pioneer in an all-pirate comic industry rather than an all-superhero one. The thing just happens to take place in the year 2020 of the Watchmen setting, in a way that’s easy to forget. Tom King and Jorge Fornés have spun the story of one private detective searching for the motive behind a failed attempt to assassinate a presidential candidate. Compared to Doomsday Clock, DC Comics’ previous continuation of Watchmen, Rorschach has been an understated experience.
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They sheltered under it but unfortunately, the goods train which did not have an engine attached to it started moving causing the accident," said a railway spokesperson.ĪLSO READ: Odisha train tragedy: Around 200 people still being treated 101 bodies yet to be identified Horrific Coromandel Express accident Researchers have used this dataset to train models to guess Pictionary-style drawings. Create digital artwork to share online and export to popular image formats JPEG, PNG, SVG, and PDF. The labourers were working at a railway siding where a goods train was standing stationary. Sketchpad: Free online drawing application for all ages. The labourers had sheltered from heavy rain under the goods train when it started rolling. These services often broadcast channels without user permission, potentially putting you at risk of breaking the law. One of the critical issues with SuperBox devices is that they come pre-installed with unverified IPTV services. 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The SuperBox may seem appealing at first glance, with its promise of thousands of live channels, series, films, and more. Do I need a subscription to use SuperBox?.What are the best SuperBox alternatives?.Final Thoughts on the SuperBox IPTV Device.SuperBox IPTV Alternatives – More Options. The paper changed its name to the Standard in 1977 but the name East African Standard was revived later. The British-based Lonrho Group bought the newspaper in 1963, only a few months before Kenya’s independence. At the time the newspaper declared strongly colonialist viewpoints. It became a daily paper and moved its headquarters from Mombasa to Nairobi in 1910. The Supreme Court ruled 5-4 that the US is not required to secure water for the Navajo Nation. In 1905 Jeevanjee sold the paper to Maia Anderson and Rudolph Franz Mayer, who changed the name to the East African Standard. Gen Ottos new role entails monitoring chapter 2 of the peace agreement which deals with peace and security. Nation.Africa is the market leader for breaking news and live sports coverage including results, video and analysis on Athletics, Nation.Africa is the market leader for sports news from Kenya and across Africa. The newspaper was established as the African Standard in 1902 as a weekly by Alibhai Mulla Jeevanjee, an immigrant businessman from British India. The Standard Group is headquartered on Mombasa Road, Nairobi, having moved from its previous premises at the I&M Bank Tower. It is the oldest newspaper in the country and is owned by The Standard Group, which also runs the Kenya Television Network (KTN), Radio Maisha, The Nairobian (a weekly tabloid) and Standard Digital which is its online platform. The Standard is one of the largest newspapers in Kenya with a 48 per cent market share. The other top newspaper in Kenya is the Standard. It is based in Westlands, Nairobi, Kenya. The media group also runs other media stations such as Kiss 100, Classic FM, and East FM. The head of Radio Maisha is Tom Japanni, KTN Managing Editor is Ellen Wanjiru, while Standard Digital Managing Editor is Carole Kimutai.The newspaper is owned by the Radio Africa Group. News Politics Investigations Fact Check Visual Explainers Malaria cases in Texas and Florida are the first US spread in 20 years, CDC says Police shooting sparks unrest in Paris suburb Mega. The top editors at the Standard Group include Kipkoech Tanui (The Standard, Daily Editions) and John Bundotich (Weekend Editions) with Charles Otieno editing The Nairobian. It is the oldest newspaper published in Kenya. Nairobi : Nation Newspaper Limited Nairobi : Nation Media Group Limited. Track elected officials, research health conditions. Nairobi, Kenya : East African Newspapers (Natrion Series) Ltd. In 1989, at a time when Kenya was going into multi-party era, the Standard Group acquired the KTN Television Channel. US News is a recognized leader in college, grad school, hospital, mutual fund, and car rankings. While I concur That There’s space for dialog involving the Patriotic Front (PF) government and the mining industry in Zambia, the farewell message from First Quantum Minerals (FQM) manager of operations Matt Pascall released by Lusaka Times on January 2, 20-19, is disgraceful. Breaking news and analysis on Kenyan politics today, including the latest coverage of the elections, Uhuru Kenyatta, Parliament, Supreme Court and more on Tuko News. It is the main rival to Kenya’s largest newspaper, the Daily Nation. 1 hr ago 2.7 percent NHIF deduction meant to attain equity, says board chair Michael Kamau National By Sharon Wanga 1 hr ago Premium Raila returns from UAE ahead of Azimio rally on punitive taxes. In 2004 the name was changed back to The Standard. It has a strong heritage in objective, truthful and candid reporting of the day’s political affairs. The British-based Lonrho Group bought the newspaper in 1963, only a few months before Kenya’s independence. The Daily Nation is Kenya’s and the region’s most widely read daily newspaper. It became a daily paper and moved its headquarters from Mombasa to Nairobi in 1910. In 1905 Jeevanjee sold the paper to Maia Anderson and Rudolph Franz Mayer, who changed the name to the East African Standard. Copies of the final prospectus supplement and the accompanying prospectus relating to the offering may be obtained from: Goldman Sachs & Co. Copies of the registration statement can be accessed through the SEC’s website at The offering was made only by means of a prospectus. Securities and Exchange Commission (SEC) and was declared effective on April 15, 2022. Chardan acted as the lead manager for the offering.Ī registration statement relating to the shares sold in this offering was filed with the U.S. LLC, BofA Securities and Evercore ISI acted as the joint book-running managers for the offering. All of the shares in the offering were sold by 4D Molecular Therapeutics. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by 4D Molecular Therapeutics, were $138.0 million. The shares of common stock issued and sold in the offering include 1,125,000 shares issued upon the exercise in full by the underwriters of their option to purchase additional shares of common stock at the public offering price, less underwriting discounts and commissions. (Nasdaq: FDMT), a clinical-stage biotherapeutics company harnessing the power of directed evolution for genetic medicines targeting large market diseases, announced today the closing of an upsized underwritten public offering of 8,625,000 shares of its common stock at a public offering price of $16.00 per share. This is an abstract that was submitted for the 2017 ARVO Annual Meeting, held in Baltimore, MD, May 7-11, 2017.EMERYVILLE, Calif., (GLOBE NEWSWIRE) - 4D Molecular Therapeutics, Inc. Moreover, hPSC-dependent disease models can be used to demonstrate functional rescue, thereby facilitating the path from proof-of-concept to clinical application. These human retinal systems – complemented by in vivo NHP studies – will aid future development of optimized vectors. This study in human retinal cell models clearly illustrates superior gene delivery of our novel retinal AAV variants discovered through Therapeutic Vector Evolution as compared to the clinically relevant AAV2. Robust transduction was also observed in the context of PR-directed gene transfer. PRs generated by a multi-step eye cup formation paradigm expressed recoverin, rhodopsin, and S and M/L opsins after 100 days in culture.Ĭomparative analysis of transduction efficiency and GFP transgene expression by our novel variants in RPEs revealed significantly higher transduction efficiencies versus AAV2 as measured by flow cytometry and western blot. To evaluate the selected variants on human RPEs, cultures were differentiated from hPSCs for 30 days, when 90% of all cells in culture expressed mature RPE markers including RPE65 and BEST1, synthesized VEGF and PEDF, and phagocytosed rod outer segments. We identified novel variants after six rounds of selection. In order to select variants with improved transduction of the NHP retina, 4DMT’s library of approximately 100 million unique AAV capsid variants was delivered via intravitreal administration. The Therapeutic Vector Evolution platform involves applying progressively more stringent selective pressures to a genetically diverse library of AAV capsids to select novel variants with improved gene delivery properties compared to the natural AAV serotypes. However, due to cross-species differences in AAV gene expression profiles and limitations of animal species to recapitulate human disease phenotypes, we have generated retinal pigment epithelium (RPE) and photoreceptors (PRs) from pluripotent stem cells (PSCs) to evaluate transduction and tropism of our novel retinal AAV vectors in human cell models. 4D Molecular Therapeutics (4DMT) has applied its Therapeutic Vector Evolution platform to discover novel adeno-associated virus (AAV) variants with superior gene delivery to the human retina following intravitreal delivery using non-human primates (NHP) as a model system. Gene therapy is a powerful approach for the treatment of inherited and complex retinal disorders. Usher recorded his vocals and then I recorded mine. He can’t fool Terry and say, ‘This is the best I can sing it.'” So since ‘8701,’ we’ve tried to give Usher songs that’ make you say, ‘Oh Usher can sing!’ Since he’s a naturalist vocalist he can get away with singing and it sounding good but Usher won’t let him get away with just singing good. I think sometimes it gets overlooked what a great vocalist he is. My goal with Usher is to create music and production that show off how good of a singer he is. They had many conversations on personal things, and how much to reveal. They talk a lot even when we’re not working on a project about life. I think Terry is more of a father figure and mentor to Usher. Jimmy Jam: “Terry and Usher have a whole other type of relationship. “Sometimes it gets overlooked what a great vocalist he is.” – producer Jimmy Jam on Usher. We went out and produced songs that portrayed that what makes the picture a well-rounded story.” What people want to hear in a confession is what you did to get yourself in trouble and the fun you had and how you went about that, ’cause those are the things people live every day. Terry Lewis: “While confessing is a great thing, I think that from a male perspective, men don’t want to hear you confess, because that just prompts issues with their relationships. Five records on this that were on the radio, but there are also five records that weren’t on the radio that are fan favorites. I think that if people wouldn’t have had the chance to hear feel good records, and it would have been hit after hit, then it wouldn’t have been the great album that it is or sold as much as it did. Usually those are the main ingredients to make a great album. It was made with a bunch of hits and feel good records. “‘Confessions’ was the best of A&R, the best of production, and the best executive. This is the song that defined the title of the album and the mind state of the rest of the record.” I took that concept and applied towards ‘All Bad’ (Confessions Part I). ‘U Make Me Wanna’ was a story, a story of him leaving who he was with to be with someone else. When we write about a song, try to make it a little more interest through the story. It’s about showing interest in the person who was singing. This was his prior getting married, getting divorced, having kids, prior than his canvas having many colors. ‘How do we make him interesting?’ was the conversation. The media wasn’t completely sold on Usher and Usher’s interest inside and outside of the music. The topic of interest of people not being interested in Usher the person was the main subject matter at that point. and Usher was about where we he was heading with this album. Jermaine Dupri: “We have just come off ‘U Got It Bad,’ one of the biggest songs off ‘8701.’ We were coming off the success of ‘U Got It Bad’ and ‘U Remind Me.’ The conversation with L.A. Lil Jon: rapper and “Confessions” producer performs on “Yeah!” Jermaine Dupri: “Confessions” producer and songwriter founder of So So Def Records In celebration of the 10th anniversary of Usher’s “Confessions,” an elite group of contributors who were involved in its creation and imperative to its plaitnum success share the story of making the album.Īndre “Dre” Harris (from Dre & Vidal): “Confessions” producerīryan-Michael Cox: “Confessions” producer and songwriter Kanye West’s ‘The College Dropout’: An Oral History The singer-songwriter took his artistry to a higher level when showcasing his vocal prowess at its fullest potential through engaging, relatable storytelling all at a time when R&B was dominating countless charts and hearts. “Confessions” introduced the becoming of a man. Usher’s ‘Confessions’ Album Hits 10 Million in U.S. Listen To Big Boi's New Sex Jam 'She Said OK' “A Long Way Home” is a story of resilience, determination, and the power of love. The reunion was emotional and powerful, and Saroo finally felt a sense of closure about his past. Saroo used Google Earth to trace his way back to his hometown in India, and eventually, he was able to reunite with his birth mother and sister. He began to have vivid memories of his life in India and decided to try to find his way back home. Saroo had a happy childhood in Australia, but as he grew older, he became increasingly curious about his birth family and his past. Eventually, he was adopted by an Australian couple and moved to Tasmania. Saroo survived on the streets of Kolkata for several weeks before being taken in by an orphanage. One night, when he was five years old, he got lost on a train and ended up in Kolkata, thousands of miles away from his home. Saroo grew up in a small village in India with his mother, brothers, and sister. Some of the key points of the book include: “A Long Way Home” is a memoir by Saroo Brierley that chronicles his journey from being a five-year-old child in India who got lost and ended up being adopted by an Australian couple, to his quest as a young adult to find his birth family. It celebrates the importance of never letting go of what drives the human spirit: hope. One day, after years of searching, he miraculously found what he was looking for and set off to find his family.Ī Long Way Home is a moving, poignant, and inspirational true story of survival and triumph against incredible odds. Eventually, with the advent of Google Earth, he had the opportunity to look for the needle in a haystack he once called home, and pore over satellite images for landmarks he might recognize or mathematical equations that might further narrow down the labyrinthine map of India. Unable to read or write or recall the name of his hometown or even his own last name, he survived alone for weeks on the rough streets of Calcutta before ultimately being transferred to an agency and adopted by a couple in Australia.ĭespite his gratitude, Brierley always wondered about his origins. This is the miraculous and triumphant story of Saroo Brierley, a young man who used Google Earth to rediscover his childhood life and home in an incredible journey from India to Australia and back again…Īt only five years old, Saroo Brierley got lost on a train in India. Now it’s Lion, the major motion picture starring Dev Patel, Nicole Kidman, and Rooney Mara-nominated for six Academy Awards! Then it became the New York Times bestseller and #1 international bestseller A Long Way Home. Doctors say otherwise, but the truth of it is that doctors in med school get about 10 hours of training on diet and supplementation combined in the 4 years of med school. These supplements help protect the healthy cells and limit the damage the chemo does to them. I have seen more then a few cancer patients doing chemo take these, and some others, and although there is no way to measure this, it seems it may have helped them. Last, just about any doctor is going to tell yu don't do this, but if it was me, I would be taking a lot of anti oxidants like Vit A, Alpha Liopic acid, Vit E, and protelytic enzymes. There are currently biotech drugs being tested and even applied in some places that are way more innocuous and maybe way more, probably a lot more effective then chemo/ Look it up on the net, and ask your doctor about that.'Īlso, there are places, in the bigger cities in the country, that are doing chemo in such a way where it is laced with a glucose component (to simplify it) in that the cancer cells having something like 10 times more insulin recepters then the regular healthy cells are targeted and the healthy cells are left alone. The science of it has improved 10 fold in the last 15/20 years, but it is still something I would never do. At the least, I think this scenario is more humane, and has a better chance of recovery or at least prolonging life in a better way then the standard process'.Ĭhemo just destroys the immune system, and the healthy surrounding cells. I would change my lifestyle, again, dramatically, take some holistic remedies, and pray. But I would still not do chemo, and probably not radiation. If the cancer has metastasized the chances of recovery decrease by a fair amount, but there is still hope. Again, that is if it is still encapsulated. That's all I would do have it cut out, and change my diet, lifestyle, radically, and do some natural (but potent) remedies that''s it. Thankfully, most of us are not in the category of nuclear radiation exposure. This is assuming I haven't come upon a heavy dose of nuclear radiation, in that case, I am probably just doing what I could to prolong my life, as opposed to stopping the cell multiplication all the way down to the cancer stem cell itself. Using cold hard statistics of survival rates of different methods and also taking into account quality of life. So before someone comes here and tells me they know someone, or that they themselves did chemo, never had it cut out, out, or did did chemo and radiation, and never changed their diet, or whatever combination of standard western medical practices they did, and that they survived, I understand it can be a success. I am going with the knowledge I have and with the odds of a complete recovery is. Maybe radiation, but probably not, but definitely not chemo. I am not doing chemo, nor probably radiation. If I had cancer and it is encapsulated, I would have it cut out, and radically change my lifestyle. I don't want do get into a long post, I could, as there is a lot to this subject, so I am going to keep it relatively short and just hit on some main general points. Click to expand.Chemo, in my opinion (and I am not a doctor, but I am basing this on conversations with a doctor, and from a lot of research I have done ) does more harm then good. |
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